MYD88 Mouse Monoclonal Antibody [Clone ID: 2E9C2]
CNY 6,653.00
货期*
5周
规格
Cited in 2 publications. |
经常一起买 (1)
Specifications
Product Data | |
Clone Name | 2E9C2 |
Applications | IHC, WB |
Recommend Dilution | WB: 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Mouse monoclonal MyD88 antibody was raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88. |
Formulation | MyD88 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | MyD88 Monoclonal Antibody is immunoaffinity chromotography purified IgG. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | myeloid differentiation primary response 88 |
Database Link | |
Background | MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues. |
Synonyms | MYD88D |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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MYD88 expression and L265P mutation in mature B-cell non-Hodgkin lymphomas.
,null,
Genetic testing and molecular biomarkers
,PubMed ID 25978699
[MYD88]
|
MYD88 expression and L265P mutation in diffuse large B-cell lymphoma.
,null,
Human pathology
,PubMed ID 23380077
[MYD88]
|
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