CIITA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CIITA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CIITA.
Formulation	CIITA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CIITA Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	class II, major histocompatibility complex, transactivator
Database Link	NP_000237 Entrez Gene 12265 MouseEntrez Gene 85483 RatEntrez Gene 4261 Human UniProt ID P33076
Background	CIITA Antibody: CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
Synonyms	C2TA; CIITAIV; MHC2TA; NLRA
Reference Data
Protein Pathways	Antigen processing and presentation, Primary immunodeficiency

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