CD168 (HMMR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	RHAMM antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human RHAMM.
Formulation	RHAMM Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	RHAMM Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	hyaluronan mediated motility receptor
Database Link	NP_036617 Entrez Gene 15366 MouseEntrez Gene 25460 RatEntrez Gene 3161 Human UniProt ID O75330
Background	RHAMM Antibody: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.
Synonyms	CD168; IHABP; RHAMM
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	ECM-receptor interaction

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