Endo G (ENDOG) Mouse Monoclonal Antibody

CAT#: TA319642

Mouse EndoG Monoclonal Antibody



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CNY 6,653.00


货期*
5周

规格
    • 100 ug

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经常一起买 (2)
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Specifications

Product Data
Applications WB
Recommend Dilution WB: 5 - 10 ug/mL
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Immunogen Recombinant protein corresponding to amino acids 51 - 140 of human EndoG.
Formulation EndoG Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification EndoG Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name endonuclease G
Background EndoG Monoclonal Antibody: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndoG also cleaves DNA in vitro.
Synonyms FLJ27463
Reference Data
Protein Families Druggable Genome
Protein Pathways Apoptosis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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