IL17F Mouse Monoclonal Antibody [Clone ID: 4H1629.1]

Specifications

Product Data
Clone Name	4H1629.1
Applications	IHC, WB
Recommend Dilution	WB: 0.5 mg/mL, IHC: 5ug/mL
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-IL-17F (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with mature full length recombinant human IL-17F produced in E.coli followed by hybridoma development.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 17F
Database Link	NP_443104 Entrez Gene 112744 Human UniProt ID Q96PD4
Synonyms	CANDF6; IL-17F; ML-1; ML1
Note	Anti-L-17F recognizes IL-17F (also known as Cytokine ML-1 or Interleukin-24). IL-17F is produced and secreted by CD8+ T cells, NK cells, NKT cells and LTi cells. The main functions of IL-17F are neutrophil recruitment and immunity to extracellular pathogen. More importantly, IL-17F drives inflammation and auto-immunity. IL-17A and IL-17F are by far the best characterized cytokines of the IL-17 cytokine family. IL-17F dimerizes in a parallel fashion similar to nerve growth factor and other neutrophins. Its dimerization is critical to fulfill its activity. When secreted by activated T cells, IL-17F can stimulate the production of other cytokines such as IL-6, IL-8 granulocyte colony-stimulating factor and, can stimulate cartilage matrix turnover. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. Anti-IL-17E cytokine antibody is ideal for investigators involved in Immunology, Signal Transduction research, Cancer and Inflammatory pathologies.
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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