PDCD4 Mouse Monoclonal Antibody [Clone ID: 9G6]
CAT#: TA319575
Mouse monoclonal Pdcd4 phospho S457 antibody (Phospho-specific)
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CNY 5,960.00
货期*
5周
规格
经常一起买 (1)
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Specifications
Product Data | |
Clone Name | 9G6 |
Applications | ELISA, WB |
Recommend Dilution | ELISA: 1:20,000 - 1:100,000, WB: 1:2,000 - 1:10,000, IP: 1:1,000 - 1:5,000 |
Reactivity | Human, Mouse, Rat, Xenopus |
Modifications | Phospho-specific |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | programmed cell death 4 (neoplastic transformation inhibitor) |
Database Link | |
Synonyms | H731 |
Note | Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. |
Reference Data | |
Protein Families | Druggable Genome |
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