PMS2 Mouse Monoclonal Antibody [Clone ID: 349.29.5.2]

Specifications

Product Data
Clone Name	349.29.5.2
Applications	WB
Recommend Dilution	ELISA: 1:5,000 - 1:20,000, WB: 1:500 - 1:2,000
Reactivity	Human, Mouse, Hamster, Rat, Chimpanzee
Host	Mouse
Clonality	Monoclonal
Immunogen	This protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human PMS2 corresponding to the first 133 amino acid residues of the protein. The clone was produced using conventional hybridoma technology.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	PMS1 homolog 2, mismatch repair system component
Database Link	NP_000526 Entrez Gene 18861 MouseEntrez Gene 288479 RatEntrez Gene 5395 Human UniProt ID P54278
Synonyms	HNPCC4; PMS2CL; PMSL2
Note	PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNA replication and has been identified to be composed as a heterodimer of PMS2 and MLH1. PMS is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4), Turcot syndrome (an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas) and supratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL). The human PMS2 gene encodes an 862 aa, 96 kDa polypeptide.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Mismatch repair

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