p21 (CDKN1A) Mouse Monoclonal Antibody [Clone ID: WA-1]

Specifications

Product Data
Clone Name	WA-1
Applications	WB
Recommend Dilution	ELISA: 1:5,000 - 1:20,000, WB: 1:2,000 - 1:10,000, IP: 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human p21 fusion protein.
Formulation	0.02 M Potassium Phosphate, 0.5 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cyclin-dependent kinase inhibitor 1A
Database Link	NP_000380 Entrez Gene 1026 Human UniProt ID P38936
Synonyms	CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1
Note	p21WAF1 is a tumor suppressor gene product critical to maintain proper regulatory control of cell division. p21WAF1 inhibits cyclin/cyclin-dependent kinase (cdk) complexes, causing cell cycle arrest by blocking cell division at the S phase. Various mutations of tumor suppressor genes have been associated with different types of cancers. In these cases, somatic gene therapy with wild-type versions of tumor suppressor genes have been contemplated as anti-cancer therapeutic approaches. p21WAF1 contains p53-binding sites in its promoter and expression of p21WAF1 is induced in WI38 fibroblasts with PMA. The induction of and
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Bladder cancer, Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Glioma, Melanoma, p53 signaling pathway, Pathways in cancer, Prostate cancer

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