Mesothelin (MSLN) Mouse Monoclonal Antibody [Clone ID: MB-G10]

Specifications

Product Data
Clone Name	MB-G10
Applications	IHC, WB
Recommend Dilution	ELISA: 1:10,000 - 1:50,000, WB: 1:1,000, IHC: 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to the extracellular domain of human mesothelin.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mesothelin
Database Link	NP_001170826 Entrez Gene 10232 Human UniProt ID Q13421
Synonyms	MPF; SMRP
Note	Anti Mesothelin Antibody recognizes Mesothelin that is a glycosyl-phosphatidylinositol–anchored glycoprotein present on the cell surface of various human solid tumors. The mesothelin (MSLN) gene encodes a 71-kDa precursor protein that is processed to a 40-kDa glycosylphosphatidylinositol–anchored protein that composes the mature portion and an NH2 terminal 31-kDa fragment called megakaryocyte-potentiating factor that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues, such as mesothelium, but aberrantly over expressed in mesotheliomas, ovarian, and pancreatic cancers. The biological functions of mesothelin remain elusive. A recent study showed that mesothelin binds to MUC16/CA125, and that this interaction mediates cell adhesion, suggesting that there may be an important role for MUC16/CA125 and mesothelin in the metastatic spread of ovarian cancer.
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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