IDO1 Mouse Monoclonal Antibody [Clone ID: 10.1]

Specifications

Product Data
Clone Name	10.1
Applications	WB
Recommend Dilution	ELISA: 1:5000-1:50000, WB: 1:500-1:1500, IHC: 1:100-1:500, IF: 1:50-1:100, IP: 10-100 uL
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-IDO1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with fragment of recombinant human and mouse IDO1 protein followed by hybridoma development.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	indoleamine 2,3-dioxygenase 1
Database Link	NP_002155 Entrez Gene 15930 MouseEntrez Gene 3620 Human UniProt ID P14902
Synonyms	IDO; IDO-1; INDO
Note	Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Tryptophan metabolism

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