MRE11 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IP
Recommend Dilution	ELISA: 1:10,000 - 1:50,000, WB: 1:500- 1:2,000
Reactivity	Saccharomyces cerevisiae
Host	Rabbit
Clonality	Polyclonal
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 578-590 of Saccharomyces cerevisiae (baker's yeast) Mre11 protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	MRE11 homolog A, double strand break repair nuclease
Database Link	NP_005581 Entrez Gene 4361 Human UniProt ID P49959
Synonyms	ATLD; HNGS1; MRE11; MRE11B
Note	Mre11 (also known as double-strand break repair protein MRE11) is a subunit of a complex with Rad50 and Xrs2 (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability. Mre11 possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity that appears to be required for RMX function. This nuclear protein is widely conserved and is also involved in meiotic double strand break processing.
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Homologous recombination, Non-homologous end-joining

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