UNC13B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	IHC:1:100-1:1000; WB:1:1000-1:10000
Reactivity	Human, Mouse, Rat, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 462 and 749 of UNC13B (Uniprot ID#O14795)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	181 kDa
Gene Name	unc-13 homolog B (C. elegans)
Database Link	NP_006368 Entrez Gene 22249 MouseEntrez Gene 64830 RatEntrez Gene 10497 Human UniProt ID O14795
Background	This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]
Synonyms	MUNC13; UNC13; Unc13h2
Note	Seq homology of immunogen across species: Mouse (98%), Rat (98%), Bovine (97%)
Reference Data
Protein Families	Druggable Genome

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