FMO1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB:1:500-1:3000
Reactivity	Human, Mouse, Dog, Pig, Rat, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 1 and 437 of FMO1 (Uniprot ID#Q01740)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	flavin containing monooxygenase 1
Database Link	NP_002012 Entrez Gene 14261 MouseEntrez Gene 25256 RatEntrez Gene 403604 DogEntrez Gene 2326 Human UniProt ID Q01740
Background	Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq]
Synonyms	Flavin-containing monooxygenase 1 (fetal liver); flavin containing monooxygenase 1; OTTHUMP00000033536; OTTHUMP00000033537
Note	Seq homology of immunogen across species: Mouse (83%), Dog (88%), Pig (86%), Rat (82%), Bovine (85%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Drug metabolism - cytochrome P450

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