PDHA1 Rabbit Polyclonal Antibody
CAT#: TA308687
Rabbit Polyclonal antibody to Pyruvate Dehydrogenase E1 alpha (pyruvate dehydrogenase (lipoamide) alpha 1)
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CNY 6,281.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
CNY 9,998.00
CNY 3,080.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:1000-1:10000 |
Reactivity | Human, Chimpanzee, Rhesus Monkey, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fragment corresponding to a region within amino acids 39 and 325 of (Uniprot ID#P08559) |
Formulation | 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
Concentration | lot specific |
Purification | Purified by antigen-affinity chromatography. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 43 kDa |
Gene Name | pyruvate dehydrogenase (lipoamide) alpha 1 |
Database Link | |
Background | The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1); dihydrolipoyl transacetylase (DLAT; MIM 608770) (E2; EC 2.3.1.12); and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]). [supplied by OMIM] |
Synonyms | PDHA; PDHAD; PDHCE1A; PHE1A |
Note | Seq homology of immunogen across species: Rhesus Monkey (100%), Chimpanzee (100%) |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Butanoate metabolism, Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Metabolic pathways, Pyruvate metabolism, Valine, leucine and isoleucine biosynthesis |
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