PRAK (MAPKAPK5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	ICC/IF:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Chicken, Pig, Rat, X. tropicalis
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment contain a sequence corresponding to a region within amino acids 197 and 457 of PRAK (Uniprot ID#Q8IW41)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	54 kDa
Gene Name	mitogen-activated protein kinase-activated protein kinase 5
Database Link	NP_620777 Entrez Gene 17165 MouseEntrez Gene 498183 RatEntrez Gene 8550 Human UniProt ID Q8IW41
Background	The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
Synonyms	MAPKAP-K5; MK-5; MK5; PRAK
Note	Seq homology of immunogen across species: Mouse (96%), Chicken (95%), Pig (97%), Rat (96%), Xenopus tropicalis (90%)
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	MAPK signaling pathway

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