NSMAF Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 262 and 570 of FAN (Uniprot ID#Q92636)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	104 kDa
Gene Name	neutral sphingomyelinase activation associated factor
Database Link	NP_001138244 Entrez Gene 18201 MouseEntrez Gene 353233 RatEntrez Gene 8439 Human UniProt ID Q92636
Background	This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
Synonyms	FAN; GRAMD5
Note	Seq homology of immunogen across species: Mouse (93%), Rat (91%)
Reference Data
Protein Families	Druggable Genome

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