alpha 1a Adrenergic Receptor (ADRA1A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Bovine, Dog, Pig, Rabbit, Guinea Pig, Rhesus Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide contain a sequence corresponding to a region within amino acids 206 and 260 of alpha 1a Adrenergic Receptor (Uniprot ID#P35348)
Formulation	1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	adrenoceptor alpha 1A
Database Link	NP_000671 Entrez Gene 403866 DogEntrez Gene 148 Human UniProt ID P35348
Background	Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq]
Synonyms	ADRA1C; ADRA1L1; ALPHA1AAR
Note	Seq homology of immunogen across species: Dog (100%), Pig (100%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%), Guinea pig (100%)
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction

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