PSMC3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:5000-1:20000
Reactivity	Human, Zebrafish, Chicken, Bovine, Rhesus Monkey, X. tropicalis, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 51 and 361 of PSMC3 (Uniprot ID#P17980)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	49 kDa
Gene Name	proteasome 26S subunit, ATPase 3
Database Link	NP_002795 Entrez Gene 19182 MouseEntrez Gene 5702 Human UniProt ID P17980
Background	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq]
Synonyms	TBP1
Note	Seq homology of immunogen across species: Mouse (100%), Zebrafish (100%), Xenopus Tropicalis (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Proteasome

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