Cofilin 2 (CFL2) Rabbit Polyclonal Antibody

CAT#: TA308342

Rabbit polyclonal antibody to Cofilin 2 (cofilin 2 (muscle))



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CNY 6,281.00


货期*
5周

规格
    • 100 ul

Product images

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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Human, Rat, Pig, Chicken, Bovine, Rhesus Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region within amino acids 92 and 166 of Cofilin 2
Formulation 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 19 kDa
Gene Name cofilin 2
Background Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]). [supplied by OMIM]
Synonyms NEM7
Note Seq homology of immunogen across species: Mouse (100%), Rat (100%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)
Reference Data
Protein Families Druggable Genome
Protein Pathways Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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