Cofilin 2 (CFL2) Rabbit Polyclonal Antibody
CAT#: TA308342
Rabbit polyclonal antibody to Cofilin 2 (cofilin 2 (muscle))
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CNY 6,281.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
CNY 9,998.00
CNY 3,080.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000 |
Reactivity | Human, Rat, Pig, Chicken, Bovine, Rhesus Monkey, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region within amino acids 92 and 166 of Cofilin 2 |
Formulation | 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
Concentration | lot specific |
Purification | Purified by antigen-affinity chromatography. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 19 kDa |
Gene Name | cofilin 2 |
Database Link | |
Background | Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]). [supplied by OMIM] |
Synonyms | NEM7 |
Note | Seq homology of immunogen across species: Mouse (100%), Rat (100%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%) |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton |
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