GBA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Chimpanzee
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 352 and 536 of GBA (Uniprot ID#P04062)
Formulation	1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	glucosylceramidase beta
Database Link	NP_001005750 Entrez Gene 2629 Human UniProt ID P04062
Background	This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]
Synonyms	acid (includes glucosylceramidase); beta; D-glucosyl-N-acylsphingosine glucohydrolase; GBA1; GCB; GLUC; glucocerebrosidase; glucocerebrosidase (alt.); glucosidase; lysosomal glucocerebrosidase; OTTHUMP00000033992; OTTHUMP00000033993
Note	Seq homology of immunogen across species: Chimpanzee (100%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism

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