ATP6V1H Rabbit Polyclonal Antibody
CAT#: TA307969
Rabbit Polyclonal antibody to ATP6V1H (ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H)
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CNY 6,281.00
Cited in 3 publications. |
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 4,840.00
CNY 4,840.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB:1:500-1:3000 |
Reactivity | Human, Mouse, Chicken, Pig, Xenopus, Zebrafish, Bovine, X. tropicalis |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fragment corresponding to a region within amino acids 169 and 444 of ATP6V1H (Uniprot ID#Q9UI12) |
Formulation | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
Purification | Purified by antigen-affinity chromatography. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 56 kDa |
Gene Name | ATPase H+ transporting V1 subunit H |
Database Link | |
Background | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit. [provided by RefSeq] |
Synonyms | CGI-11; MSTP042; NBP1; SFD; SFDalpha; SFDbeta; VMA13 |
Note | Seq homology of immunogen across species: Chicken (96%), Pig (99%), Xenopus laevis (94%), Zebrafish (91%), Bovine (98%), Xenopus tropicalis (94%) |
Reference Data | |
Protein Pathways | Epithelial cell signaling in Helicobacter pylori infection, Lysosome, Metabolic pathways, Oxidative phosphorylation, Vibrio cholerae infection |
Citations (3)
The use of this Antibodies has been cited in the following citations: |
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ATP6V1H regulates the growth and differentiation of bone marrow stromal cells
,Li, L;Yang, S;Zhang, Y;Ji, D;Jin, Z;Duan, X;,
Biochem. Biophys. Res. Commun.
,PubMed ID 29782852
[ATP6V1H]
|
Analysis of two transcript isoforms of vacuolar ATPase subunit H in mouse and zebrafish
,Zhao, W;Zhang, Y;Yang, S;Hao, Y;Wang, Z;Duan, X;,
Gene
,PubMed ID 28970149
[ATP6V1H]
|
Deficiency of ATP6V1H Causes Bone Loss by Inhibiting Bone Resorption and Bone Formation through the TGF-ß1 Pathway
,Duan, X;Liu, J;Zheng, X;Wang, Z;Zhang, Y;Hao, Y;Yang, T;Deng, H;,
Theranostics
,PubMed ID 27924156
[ATP6V1H]
|
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