LXR beta (NR1H2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	LXR-B antibody was raised against a 14 amino acid peptide from near the amino terminus human LXR-B.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	nuclear receptor subfamily 1 group H member 2
Database Link	NP_009052 Entrez Gene 22260 MouseEntrez Gene 58851 RatEntrez Gene 7376 Human UniProt ID P55055
Background	LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRa, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer’s disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the e3 allele.
Synonyms	LXR-b; LXRB; NER; NER-I; RIP15; UNR
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

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