MED4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 0.5 ug/mL, ICC: 10 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	MED4 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MED4.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mediator complex subunit 4
Database Link	NP_054885 Entrez Gene 67381 MouseEntrez Gene 306030 RatEntrez Gene 29079 Human UniProt ID Q9NPJ6
Background	The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED4. This protein has also been shown to be part of the vitamin D receptor interacting complex. MED4 was recently identified as an HIV dependency factor (HDF), suggesting that MED4 may be an important drug target in HIV treatment. At least three isoforms of MED4 are known to exist; this antibody only recognizes the largest isoform.
Synonyms	ARC36; DRIP36; HSPC126; TRAP36; VDRIP
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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