GPR124 (ADGRA2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 2 - 4 ug/mL, ICC: 5 ug/mL
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TEM5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human TEM5.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	adhesion G protein-coupled receptor A2
Database Link	NP_116166 Entrez Gene 100363275 RatEntrez Gene 25960 Human UniProt ID Q96PE1
Background	Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
Synonyms	GPR124; TEM5
Reference Data
Protein Families	Druggable Genome, Transmembrane

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