DARC (ACKR1) Rabbit Polyclonal Antibody

CAT#: TA306405

Rabbit Polyclonal DARC Antibody



Need it in bulk or conjugated?
Get a free quote

CNY 5,808.00


货期*
5周

规格
    • 100 ug

Product images

经常一起买 (4)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00


Recombinant protein of human Duffy blood group, chemokine receptor (DARC), transcript variant 2, 20 µg
    • 20 ug

CNY 2,900.00
CNY 6,650.00


Transient overexpression lysate of Duffy blood group, chemokine receptor (DARC), transcript variant 2
    • 100 ug

CNY 3,080.00


Transient overexpression lysate of Duffy blood group, chemokine receptor (DARC), transcript variant 1
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen DARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name atypical chemokine receptor 1 (Duffy blood group)
Background DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.
Synonyms CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...