ATM Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 10 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	ATM antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ATM serine/threonine kinase
Database Link	NP_000042 Entrez Gene 472 Human UniProt ID Q13315
Background	DNA double strand breaks represent a major threat to an organism’s genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.
Synonyms	AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transcription Factors
Protein Pathways	Apoptosis, Cell cycle, p53 signaling pathway

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