ASK1 (MAP3K5) Rabbit Polyclonal Antibody

CAT#: TA306285

Rabbit Polyclonal ASK1 Antibody



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CNY 5,808.00


货期*
4周

规格
    • 100 ug

Product images

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1 - 2 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen ASK1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human ASK1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name mitogen-activated protein kinase kinase kinase 5
Background Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5 (1-3). ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-Α-induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.
Synonyms ASK1; MAPKKK5; MEKK5
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Neurotrophin signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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