CTRP3 (C1QTNF3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	CTRP3 antibody was raised against a 16 amino acid synthetic peptide from near the center of human CTRP3. The immunogen is located within amino acids 90 - 140 of CTRP3.
Formulation	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	C1q and tumor necrosis factor related protein 3
Database Link	NP_852100 Entrez Gene 114899 Human UniProt ID Q9BXJ4
Background	Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues (3). An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). Multiple isoforms of human CTRP3 have been reported. It has been suggested that CTRP3 may play a role in skeletal development (5).
Synonyms	C1ATNF3; CORCS; CORS; CORS-26; CORS26; CTRP3
Reference Data

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