Tuberin (TSC2) Rabbit Polyclonal Antibody
CNY 5,808.00
CNY 300.00
CNY 1,430.00
CNY 4,840.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 2 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | TSC2 (NT) was raised against a 14 amino acid peptide from near the amino terminus of human TSC2. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | tuberous sclerosis 2 |
Database Link | |
Background | Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). At least three isoforms of TSC2 exist. |
Synonyms | LAM; PPP1R160; TSC4 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Insulin signaling pathway, mTOR signaling pathway, p53 signaling pathway |
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