Caspase 5 (CASP5) Rabbit Polyclonal Antibody

CAT#: TA306198

Rabbit Polyclonal Caspase-5 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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经常一起买 (2)
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Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 2 ug/mL
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Caspase-5 antibody was raised against a 14 amino acid peptide from the center of human Caspase-5.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name caspase 5
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-ϒ (5).
Synonyms ICE(rel)III; ICEREL-III; ICH-3
Reference Data
Protein Families Druggable Genome, Protease
Protein Pathways NOD-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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