IRF3 Rabbit Polyclonal Antibody
CNY 5,808.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 1 - 4 ug/mL, ICC: 2 ug/mL, IF: 2 ug/mL |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | IRF3 antibody antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF3. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | interferon regulatory factor 3 |
Database Link | |
Background | Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells (2). Following viral infection, IRF3 can be activated by IkappaB kinase-epsilon and TANK-binding kinase 1 (TBK1) (3,4), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA (3,5). IRF3 exists as at least two distinct isoforms. |
Synonyms | interferon regulatory factor 3; MGC94729 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |