BID Rabbit Polyclonal Antibody

CAT#: TA306178

Rabbit Polyclonal Bid Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 0.5 - 2 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Bid antibody was raised against a peptide corresponding to 14 amino acids near the middle of human Bid.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Ion exchange chromatography purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name BH3 interacting domain death agonist
Background Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals (4,5), exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein (6). The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize (7,8).
Synonyms FP497
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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