ACE2 Rabbit Polyclonal Antibody (Angiotensin Converting Enzyme 2)

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	angiotensin I converting enzyme 2
Database Link	NP_068576 Entrez Gene 59272 Human UniProt ID Q9BYF1
Background	Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology (1-2). In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus (3). The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function (4).
Synonyms	ACEH
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Renin-angiotensin system

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