Bcl2 Binding component 3 (BBC3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 2 ug/mL, IHC: 10 ug/mL, IF: 10 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	PUMA antibody was raised against a synthetic peptide corresponding to 14 amino acids near the amino terminus of human PUMA-a This sequence is identical between a and b ?forms of the PUMA proteins.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BCL2 binding component 3
Database Link	NP_055232 Entrez Gene 27113 Human UniProt ID Q96PG8
Background	Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Synonyms	JFY-1; JFY1; PUMA
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease, p53 signaling pathway

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