IKK gamma (IKBKG) Rabbit Polyclonal Antibody
CNY 5,808.00
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CNY 300.00
CNY 1,430.00
CNY 9,998.00
CNY 4,840.00
Specifications
Product Data | |
Applications | ELISA, ICC, IF, WB |
Recommend Dilution | IKK gamma antibody can be used for detection of IKK gamma by Western blot at 1 µg/mL. A 52 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | IKK gamma antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK gamma. The immunogen is located within the last 50 amino acids of IKK gamma. |
Specificity | IKK gamma has no cross response to IKK alpha or IKK beta. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | IKK gamma Antibody is DEAE purified. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
Database Link | |
Background | Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The IkB kinase (IKKalpha and IKKbeta) phosphorylates IkB and mediates NF-kappaB activation. A novel molecule in the IKK complex was recently identified and termed IKKgamma/NEMO/FIP3/IKKAP1 (1-5). IKKg interacts with IKKbeta and is required for the activation of IKK complex and NF-kappaB by LPS, PMA, TNF, and IL-1 stimulation (1-4). FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-kappaB activation (3). |
Synonyms | AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9 |
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