IKK gamma (IKBKG) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC, IF, WB
Recommend Dilution	IKK gamma antibody can be used for detection of IKK gamma by Western blot at 1 µg/mL. A 52 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	IKK gamma antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK gamma. The immunogen is located within the last 50 amino acids of IKK gamma.
Specificity	IKK gamma has no cross response to IKK alpha or IKK beta.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	IKK gamma Antibody is DEAE purified.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Database Link	AF074382 Entrez Gene 8517 Human UniProt ID Q9Y6K9
Background	Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The IkB kinase (IKKalpha and IKKbeta) phosphorylates IkB and mediates NF-kappaB activation. A novel molecule in the IKK complex was recently identified and termed IKKgamma/NEMO/FIP3/IKKAP1 (1-5). IKKg interacts with IKKbeta and is required for the activation of IKK complex and NF-kappaB by LPS, PMA, TNF, and IL-1 stimulation (1-4). FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-kappaB activation (3).
Synonyms	AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Reference Data

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