CNKSR1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC, WB
Recommend Dilution	WB: 0.5-2 µg/mL; ICC: 5 µg/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunocytochemistry in human samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	AIF antibody was raised against a peptide corresponding to amino acids 593 to 606 of human AIF. This sequence is identical to those of mouse and rat AIF.
Specificity	Multiple isoforms of AIF are known to exist.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	AIF Antibody is DEAE purified.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	connector enhancer of kinase suppressor of Ras 1
Database Link	NP_006305 Entrez Gene 194231 MouseEntrez Gene 298545 RatEntrez Gene 10256 Human UniProt ID Q969H4
Background	Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins (1). A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF) (2). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed (2).
Synonyms	CNK; CNK1
Reference Data
Protein Families	Druggable Genome

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