NCOA62 (SNW1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL, ICC: 20 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SkiP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human SkiP .
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	SNW domain containing 1
Database Link	NP_036377 Entrez Gene 66354 MouseEntrez Gene 500695 RatEntrez Gene 22938 Human UniProt ID Q13573
Background	TGF-beta and the bone morphogenic proteins (BMPs) are key signaling proteins that regulate numerous cellular processes such as embryonic development and tumorigenesis (1). Both signal through the Smad protein family and are negatively regulated by Ski and SnoN, two related proto-oncoproteins (2,3). Ski functions by binding to the Smad proteins activated by TGF-beta and the (BMPs) and preventing their phosphorylation, inhibiting their ability to bind DNA and activate the transcription of downstream genes (4,5). SkiP was originally identified as a Ski-interacting protein (6) and was later found to augment the signals induced by TGF-beta but inhibit transcription induced by BMP-2 (7) in C2C12 cells, suggesting that SkiP is a key player in the signaling cascades inititated by TGF-beta and the BMP protein family.
Synonyms	Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Notch signaling pathway, Spliceosome

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