RIP2 (RIPK2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	RICK antibody was raised against a peptide corresponding to amino acids 508 to 522 of human origin .
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	receptor interacting serine/threonine kinase 2
Database Link	NP_003812 Entrez Gene 8767 Human UniProt ID O43353
Background	Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues (1).
Synonyms	CARD3; CARDIAK; CCK; GIG30; RICK; RIP2
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Neurotrophin signaling pathway, NOD-like receptor signaling pathway

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