APAF1 Rabbit Polyclonal Antibody

CAT#: TA305972

Rabbit Polyclonal Apaf1 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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经常一起买 (1)
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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 1 ug/mL, IHC: 1 ug/mL, IF: 10 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Apaf1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Apaf1. The sequences of the immunogenic peptide are identical between human and mouse.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name apoptotic peptidase activating factor 1
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Apaf1 can also associate with caspase-4 and caspase-8 (4). Apaf1 is ubiquitously expressed in human tissues .
Synonyms APAF-1; CED4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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