ASK1 (MAP3K5) Rabbit Polyclonal Antibody

CAT#: TA305959

Rabbit Polyclonal ASK1 Antibody



Need it in bulk or conjugated?
Get a free quote

CNY 5,808.00


货期*
5周

规格
    • 100 ug

Product images

经常一起买 (4)
Transient overexpression lysate of mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
    • 100 ug

CNY 3,080.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00


Recombinant protein of human mitogen-activated protein kinase kinase kinase 5 (MAP3K5), 20 µg
    • 20 ug

CNY 2,900.00
CNY 6,650.00


Recombinant protein of human mitogen-activated protein kinase kinase kinase 5 (MAP3K5), 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Applications ELISA, ICC, IF, WB
Recommend Dilution ASK1 antibody can be used for detection of ASK1 by Western blot at 0.5 µg/mL. A 155 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen ASK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human ASK1 This sequence is different from that of mouse by last two amino acids.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification ASK1 Antibody is DEAE purified.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name mitogen-activated protein kinase kinase kinase 5
Background Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-alpha-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Synonyms ASK1; MAPKKK5; MEKK5
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Neurotrophin signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...