CCR3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CCR3 antibody was raised against a 14 amino acid peptide from near the amino terminus of human CCR3.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Immunoaffinity purified IgG
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	C-C motif chemokine receptor 3
Database Link	NP_847899 Entrez Gene 1232 Human UniProt ID P51677
Background	Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells (1-4). CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems (5). The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.
Synonyms	CC-CKR-3; CD193; CKR3; CMKBR3
Reference Data

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