Neurokinin 1 Receptor (TACR1) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blot: 0.3-1µg/ml. 1 h at RT. Approx 48kDa band observed in lysates of cell lines HeLa and Neuro2a (calculated MW of 46.3kDa according to Human NP_001049.1 and Mouse NP_033339.2 ). Immunofluorescence: 10µg/ml. Expression of the protein seen in the plasma membrane and nucleus of Neuro2a cells.
Reactivity	Human, Mouse, Rat, Dog
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-EIPGDSSDRYHEQ, from the internal region of the protein sequence according to NP_001049.1*; NP_056542.1*.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tachykinin receptor 1
Database Link	NP_001049 Entrez Gene 21336 MouseEntrez Gene 24807 RatEntrez Gene 403815 DogEntrez Gene 6869 Human UniProt ID P25103
Background	This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq]
Synonyms	NK1R; NKIR; SPR; TAC1R
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Calcium signaling pathway, Neuroactive ligand-receptor interaction

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.