NQO1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1:64000. WB: 0.03-0.1µg/ml.IHC:5µg/ml;IF:5µg/ml
Reactivity	Human, Mouse, Dog, Rat, Pig
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-SIPTDNQIKARK, from the C Terminus of the protein sequence according to NP_000894.1; NP_001020604.1; NP_001020605.1.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30.7 kDa
Gene Name	NAD(P)H quinone dehydrogenase 1
Database Link	NP_000894 Entrez Gene 18104 MouseEntrez Gene 24314 RatEntrez Gene 610935 DogEntrez Gene 1728 Human UniProt ID P15559
Background	This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Synonyms	DHQU; DIA4; DTD; NMOR1; NMORI; QR1
Reference Data
Protein Families	Druggable Genome

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