GNRHR Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:32,000. WB: 0.5-1.5µg/ml.
Reactivity	Human, Dog
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-QKWTQKKEKGK, from the internal region of the protein sequence according to NP_000397.1; NP_001012781.1.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	41356 Da
Gene Name	gonadotropin releasing hormone receptor
Database Link	NP_000397 Entrez Gene 403718 DogEntrez Gene 2798 Human UniProt ID P30968
Background	This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq]
Synonyms	GNRHR1; GRHR; HH7; LHRHR; LRHR
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	GnRH signaling pathway, Neuroactive ligand-receptor interaction

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