Caspase 3 (CASP3) Mouse Monoclonal Antibody [Clone ID: CPP32 4-1-18]

Specifications

Product Data
Clone Name	CPP32 4-1-18
Applications	ICC/IF, IHC, IP, Simple Western, WB
Recommend Dilution	Immunohistochemistry-Frozen, Western Blot: 1:500-1:1000, Simple Western: 1:2000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry: 1:200-1:500, Immunoprecipitation: 2 ug / mg lysate, Immunocytochemistry/ Immunofluorescence: 2 ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length recombinant human Caspase 3 protein.
Formulation	0.1% sodium azide
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 3
Database Link	NP_116786 Entrez Gene 836 Human UniProt ID P42574
Background	Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Synonyms	CPP32; CPP32B; SCA-1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protease
Protein Pathways	Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis

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