ATP7B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, Immunoblotting, IP, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 2 - 10 ug/mL, Immunohistochemistry: 1:100 - 1:500, Immunohistochemistry-Paraffin: 1:100 - 1:500, Immunoprecipitation, Western Blot: 1:1000, Immunoblotting
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an internal sequence near the N-terminus of human ATP7b.
Formulation	Tris citrate/phosphate [pH 7-8] and 0.1% sodium azide
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ATPase copper transporting beta
Database Link	NP_000044 Entrez Gene 11979 MouseEntrez Gene 540 Human UniProt ID P35670
Background	ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver.
Synonyms	PWD; WC1; WD; WND
Reference Data
Protein Families	Druggable Genome, Transmembrane

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.