DNMT3A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, IP, WB
Recommend Dilution	Immunohistochemistry: 1:200, Immunocytochemistry/ Immunofluorescence: 1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	This antibody was raised against amino acids 10-118 of the human DNMT3a protein.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	DNA (cytosine-5-)-methyltransferase 3 alpha
Database Link	NP_072046 Entrez Gene 1788 Human UniProt ID Q9Y6K1
Background	Inactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT3a) is necessary for the maintenance of the methylation process.
Synonyms	DNMT3A2; M.HsaIIIA; TBRS
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cysteine and methionine metabolism, Metabolic pathways

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