Caspase-7 (CASP7) Mouse Monoclonal Antibody

Specifications

Product Data
Applications	Simple Western, WB
Recommend Dilution	Western Blot: 1:500-1:1000, Simple Western: 1:500, Knockdown Validated
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length recombinant human Caspase 7 protein
Formulation	Ascitic fluid and 0.1% sodium azide
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 7
Database Link	NP_203125 Entrez Gene 12369 MouseEntrez Gene 64026 RatEntrez Gene 840 Human UniProt ID P55210
Background	Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Synonyms	CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Alzheimer's disease, Apoptosis

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