Apolipoprotein A V (APOA5) Mouse Monoclonal Antibody [Clone ID: 1G5G9]

Specifications

Product Data
Clone Name	1G5G9
Applications	ELISA, FC, ICC/IF, IHC, WB
Recommend Dilution	ELISA: 1:100-1:2000, Western Blot: 1:500-1:2000, Immunocytochemistry/ Immunofluorescence: 1:200-1:1000, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Ni-NTA purified full-length recombinant human APOA5 expressed in E. Coli strain BL21 (DE3).
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	apolipoprotein A5
Database Link	NP_443200 Entrez Gene 116519 Human UniProt ID Q6Q788
Background	Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four-fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-4 (PPAR-alpha) agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentrations than other apolipoproteins.
Synonyms	APOAV; RAP3
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	PPAR signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.