RAD21 Mouse Monoclonal Antibody [Clone ID: CM110-2C10]

Specifications

Product Data
Clone Name	CM110-2C10
Applications	Simple Western, WB
Recommend Dilution	Western Blot: 1:500 (ECL), Simple Western: 1:50
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	An N-terminal fusion protein of the C-terminal fragment of Scc1 subunit human cohesin (amino acids 544-631 of hRad21)
Formulation	PBS and 0.1% sodium azide
Concentration	lot specific
Purification	IgG purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	RAD21 cohesin complex component
Database Link	NP_006256 Entrez Gene 19357 MouseEntrez Gene 5885 Human UniProt ID O60216
Background	The cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit (Mcd1/Scc1/hRad21), allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis (2).
Synonyms	CDLS4; hHR21; HR21; HRAD21; MCD1; NXP1; SCC1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle

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